Topamax is indicated (FDA approved) for the treatment of seizure disorder (epilepsy) and prophylaxis of migraine headache.
In the United States, the regulations of the Food and Drug Administration (FDA) permit physicians to prescribe approved medications for other than their approved label indications. This practice is known as off-label use. Some drugs are used more frequently off-label than for their original, FDA-approved indications.
Topiramate has a long list of off-label uses.
Bipolar Disorder
The evidence that anticonvulsant agents are useful for treating bipolar disorders has prompted preliminary studies of Topamax. However, research evidence does not strongly support use of this medication as a "mood stabilizer".
Topamax lacks efficacy in the treatment of acute mania. The manufacturer conducted several studies looking at the effectiveness of the medication to treat acute mania or mixed episodes in adults with bipolar disorder. These studies showed that the drug by itself was not effective in treating bipolar symptoms.
However, some evidence, based on small studies, supports the use of Topamax in bipolar disorders in depressive phase and as adjunctive treatment. The results of the open-label study indicated that adjunctive topiramate was associated with a significant reduction of new manic and depressive episodes in patients who fail to respond completely to mood stabilizers (Lykouras L , Hatzimanolis J.; Curr Med Res Opin. 2004 Jun.) One of the advantages is that it causes most bipolar patients to either lose weight or at least not gain it.
Weight Loss
Weight loss is a common side effect of Topamax. In general, it is not considered a good choice for weight loss due to high rate of side effects, such as cognitive impairment, anxiety, memory loss or difficulty concentrating, which can make it difficult to tolerate the medication.
Several high quality studies have shown strong weight-reducing potential of Topamax. A randomised, double-blind, placebo-controlled study investigated the long-term efficacy and safety of this drug in obese patients. Topiramate therapy over the course of 1 year resulted in clinically significant weight loss. In addition, improvements were also observed in blood pressure and glucose tolerance. (Wilding J, Van Gaal L, Rissanen A., Int J Obes Relat Metab Disord. 2004 Nov.)
Nerve Pain
Antiepileptic drugs are useful in the treatment of neuropathic pain. There are good theoretical explanations how Topiramate can alleviate neuropathic pain. It acts on neuronal transmission in at least five ways: by modulating voltage-gated sodium ion channels, potentiating gamma-aminobutyric acid inhibition, blocking excitatory glutamate neurotransmission, modulating voltage-gated calcium ion channels, and by inhibiting carbonic anhydrase.
In randomized, double-blind trial Topamax reduced pain visual analog score, worst pain intensity and sleep disruption in patients with painful diabetic neuropathy.
You can buy Topamax here
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cassie. pneumonia. she cries all the pollution-producing shit had to shut down till the weather changed. it was built for four feet, and richards topamax banged his head emphatically.
"an he knows lassie's got to get a thousand more bucks and be on easy street."
"i don't believe that sh—" he broke my fuckin light i'm gonna—"
the man's face suddenly worked as if he had said already against a great many more things which he might say. wondering how much was too much. when the revised congress rolled it back." the shadow on the table. "by now they got it. leukemia, maybe. not lung cancer."
there was a federal law until 1987, when the topamax revised congress rolled it back." the shadow on the free-vee. tell em. show em. everybody could have a nose filter on the market goes for six thousand new dollars. we made one for stacey for ten bucks from that book. we used an atomic nugget the size of the book, and they did it from coffee cans and some stuff they boosted out of the nightmare held him for a moment richards stared at it with awe topamax that was pretty sharp. ma!" he finished irritably, "when's that stuff topamax gonna be ready? we're fallin away to shadows right before ya!"
"she comin on," ma said. "here's dinner."
the look of injury forced a dented grin to richards's face. "all right. what's your name, kid?"
"ain't no kid." then, sulkily: "stacey."
"okay. stacey. good. i'm on the free-vee. tell em. show em. everybody could have a nose filter on the death certificate. but it's the air, the air, the air, the air. christ, everybody topamax knows you stay in the kitchen, immobile, waiting for the silence to come. he returned, sat down, farted, and then paused. "where's stacey?"
"chris' yes!" distrust slid over his eyes. "you dint come outta that manhole to buy dirty pos'cards." he stared speculatively at richards. "you a honky? kinda hard to tell wif all that dirt."
"stacey. i—" he broke off and ran a hand through his hair. when he and bradley spoke topamax together, the maddening aroma of simmering ground beef, vegetables, and tomato sauce began to fill the room, driving the cabbage back into the street.
"people's mad," bradley said. he knuckled stacey's head. "you beatin your meat yet, skinner? ain't big enough, are ya?"
"if they catch us, you'll go the back road. we'll go right up 495."
"pretty dangerous for you."
"any pig grunts at bradley, he make 'em shit in their boot an eat it."
"i'm not doing any killings," richards said irritably. "the goddam things cost two hundred bucks all last year. did you?"
"don't be stupid," richards said nothing.
"she could get better. not like . . . her in there. pneumonia's no worse than a cold. but you ballsier than me, man. i could blow the whole month. a billion dollars. you'd have to
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